SUPPLEMENTAL DATA FOR Evolutionary Relationships of Microbial Aromatic Prenyltransferases
نویسندگان
چکیده
Fnq26* Streptomyces cinnamonensis CAL34104 [2] Fur7* Streptomyces sp. KO-3988 BAE78975 [3] NphB* Streptomyces sp. Strain Cl190 1ZB6_A [4] NovQ* Streptomyces niveus DSM 40088 AAF67510 [5] EpzP* Streptomyces cinnamonensis ADQ43372 [6] PpzP* Streptomyces anulatus CAX48655 [7] PtfAt* Aspergillus terreus NIH2624 EAU39467 PtfBf* Botryotinia fuckeliana B05.10 EDN25735 PtfSs* Sclerotinia sclerotiorum 1980 EDN93598 [8]
منابع مشابه
Evolutionary Relationships of Microbial Aromatic Prenyltransferases
The linkage of isoprenoid and aromatic moieties, catalyzed by aromatic prenyltransferases (PTases), leads to an impressive diversity of primary and secondary metabolites, including important pharmaceuticals and toxins. A few years ago, a hydroxynaphthalene PTase, NphB, featuring a novel ten-stranded β-barrel fold was identified in Streptomyces sp. strain CL190. This fold, termed the PT-barrel, ...
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Terpenoids are arguably the largest and most diverse family of natural products, featuring prominently in e.g. signalling, self-defence, UV-protection and electron transfer. Prenyltransferases are essential players in terpenoid and hybrid isoprenoid biosynthesis that install isoprene units on target molecules and thereby often modulate their bioactivity. In our search for new prenyltransferase ...
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Prenylation plays a major role in the diversification of aromatic natural products, such as phenylpropanoids, flavonoids, and coumarins. This biosynthetic reaction represents the crucial coupling process of the shikimate or polyketide pathway providing an aromatic moiety and the isoprenoid pathway derived from the mevalonate or methyl erythritol phosphate (MEP) pathway, which provides the preny...
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